中药材2011，Vol.34Issue(1)：119-122,4.
异长春花碱脂质体的制备及理化性质研究
Preparation and Physicochemical Properties of Vinorelbine Liposomes
摘要
Abstract
Objective :To prepare the vinorelbine liposomes and investigate their physicochemical properties. Methods:Vinorelbine liposomes were prepared by thin-film ultrasonication method. The morphology of the liposomes was detected by transmission electron microscopy. The partical size distribution and zeta potential were investigated by laser scattering. Sephadex G-50 was applied to separate the free drug and liposomes in order to determine the entrapment efficiency and leakage efficiency of the liposomes. The release characteristics of vinorelbine liposomes were measured by dialysis method. Results:The particle size of the liposome was 149.2 nm, the bilayer of the liposome was observed obviously. The zeta potential was 38.62 my. The entrapment efficiency of vinorelbine liposomes was more than 85％ (n = 3 ), and the leakage efficiency was less than 9. 0％ preserved in refrigerator( ＜ 4℃ ). In vitro release test, it could sustain for 24h and conform to the Higuchi model. Conclusion: The vinorelbine liposomes have uniform partical size, fine-looking, high entrapment efficiency and sustained releasing effect.关键词
异长春花碱/脂质体/理化性质分类
医药卫生引用本文复制引用
李学涛,程岚,贾天柱..异长春花碱脂质体的制备及理化性质研究[J].中药材,2011,34(1):119-122,4.基金项目
辽宁中医药大学青年药学人才基金(yxrc0911) （yxrc0911）
