中国组织工程研究与临床康复2011，Vol.15Issue(10)：1847-1850,4.DOI:10.3969/j.issn.1673-8225.2011.10.030
中药诱导骨髓间充质干细胞的成骨分化
Chinese herbs for inducing osteogenic differentiation of bone marrow mesenchymal stem cells
摘要
Abstract
BACKGROUND: Some Chinese herbs can induce osteogenic differentiation of mesenchymal stem cells (MSCs). The potency of MSCs differentiate into osteogenesis has a theoretical communication with traditional Chinese medicine (TCM) treatment of osteoporosis, fractures, bone necrosis, bone defects and other bone-related diseases.OBJECTIVE: To understand the researching status of osteogenic differentiation of MSCs induced by Chinese herbs so as to esta blish further researching foundation.METHODS: CNKI database (2000-01/2010-06) and PubMed (2000-01/2010-06) were retrieved by the first author, with the key words of "Chinese herb, mesenchymal stem cells, osteogenic differentiation" in Chinese and in English. The literatu res were limited to Chinese and English languages. Literatures concerning TCM monomer, single Chinese herb, Chinese herbal compound,and serum containing Chinese herb inducing osteogenic differentiation of MSCs in vivo and in vitro, human and animal were included. Repetitive studies were excluded.RESULTS AND CONCLUSION: A total of 32 literatures were included, including 2 documents addressing research background of MSCs, 5 single Chinese herbs (4 kidney-nourished herbs and 1 Qi-nourished herb), 10 Chinese herbal compound (6 kidney-nourished formulas and 4 kidney-nourished and activating blood formulas), 15 effective components of Chinese medicine.The kidney-nourished Chinese herbs, Qi- nourished herbs and activating blood herbs can induce MSCs into osteogenic differentiation, but the kidney-nourished Chinese herbs are majority. It explores the scientific value of the theory of "kidney control bone" and supply more resources of seed cells for a large number of amplification of MSCs in vitro, osteogenic differentiation and bone tissue engineering.关键词
中药/骨髓间充质干细胞/成骨分化/单味中药/中药复方分类
基础医学引用本文复制引用
杨锋,唐德志,卞琴,王拥军,施杞..中药诱导骨髓间充质干细胞的成骨分化[J].中国组织工程研究与临床康复,2011,15(10):1847-1850,4.基金项目
国家重点基础研究发展计划(973计划)资助项目(2010CB30400) （973计划）
国家自然科学基金重点项目(30930111) （30930111）
上海市科委基础重点项目(07JC14050). （07JC14050）
