实用医学杂志2011，Vol.27Issue(8)：1359-1361,3.DOI:10.3969/j.issn.1006-5725.2011.08.014
低蛋白壳聚糖神经导管组织相容性的实验研究
Experimental study on histocompatibility of nerve guide conduit contented chitosan of lower protein
刘小华 1邱伟 1李舒梅 1董明华 1张宏宇 1杨宇民2
作者信息
- 1. 341000,江西省赣州市,赣南医学院预防医学系
- 2. 226001,江苏省南通市,江苏省神经再生重点实验室
- 折叠
摘要
Abstract
Objective To study the histocompatihility of nerve guide conduit contented chitosan of lower protein. Methods According to Biological Assessment Standards of Medical Apparatus and Instrument GB/T 16886.6- 1997 , the histocompatibility of nerve guide conduit contented chitosan of lower protein was evaluated after being implanted into subcutaneous tissue of rabbit back in 1 ,2,4,12 weeks, respectively. Results General condition and wound healing of raBbit were fine after subcutaneous implantation. Under gross observation , the size of nerve guide conduit was gradually decreased and combined to the surrounding tissue after implantation , especially at week 4. Under histological observation , structure of conduit could be seen very distinctly , and there were lots of neutrophile granulocytes gathered around the nerve guide conduit , hut didn ' t fih rohlasts at week 1 ; The structure of conduit could be seen distinctly , and there were few neutrophile granulocytes gathered around nerve guide conduit ,and so did lots of fibrohlasts at week 2 ; Some branches and blood vessels could be seen at the surface of conduit , the structure of conduit appeared dimly , and fibroblasts were decreased at week 4. Lots of branches and blood vessels could he seen at the surface of conduit , the structure of conduit appeared very dimly at week 12. Conclusion Nerve guide conduit contented chitosan of lower protein is histocompatible , degradable and bioactive for rabbit.关键词
壳聚糖/神经导管/组织相容性/家兔引用本文复制引用
刘小华,邱伟,李舒梅,董明华,张宏宇,杨宇民..低蛋白壳聚糖神经导管组织相容性的实验研究[J].实用医学杂志,2011,27(8):1359-1361,3.
