实用医学杂志2011，Vol.27Issue(8)：1367-1369,3.DOI:10.3969/j.issn.1006-5725.2011.08.018
急性髓性白血病患者herg mRNA的表达及临床意义
Expression of herg mRNA in patients with de novo acute myeloid leukemia and its clinical significance
摘要
Abstract
Objective To explore the expression level of herg mRNA in patients with de novo acute myeloid leukemia (AML) and to analyze its clinical significance. Methods Expression levels of herg mRNA in peripheral blood were detec ted by real-time quantitative PCR in 48 patients and 15 healthy subjects. The relation of herg mRNA level with the clinical and hematological characteristics and treatment outcomes (CR rate and relapse rate)were analyzed. Results The expression of herg mRNA was detectable in 38 of 48 (79.17％) patients with AMI. The median value of expression level was markedly lower in the patients than in the healthy controls (0.03％ [0.00 ～2.49]％ vs. 0.35％ [0.04 ～ 1.09]％ ,P = 0.00). The expression level of herg mRNA was not obviously related with the clinical and henatological characteristics. The rate of complete remission was higher in the herg mRNA-negativepatients than in those with herg mRNA expression (90％ vs. 81.58％ ,P= 0.53), and the relapse rate was lower (44.44％ vs. 65.38％,P= 0.27). Conclusions The patients with acute myeloid leukemia have a lower expression level of herg mRNA than the healthy people. No definite association of herg mRNA expression with the prognosis of the disease is found.关键词
白血病/髓样/急性/herg/实时定量PCR/预后引用本文复制引用
耿素霞,杜欣,翁建宇,郭荣,钟立业,陆泽生,吴穗晶..急性髓性白血病患者herg mRNA的表达及临床意义[J].实用医学杂志,2011,27(8):1367-1369,3.基金项目
广东省中医药局课题(编号:2008373,2009116) （编号:2008373,2009116）
