中国组织工程研究与临床康复2011，Vol.15Issue(13)：2403-2407,5.DOI:10.3969/j.issn.1673-8225.2011.13.029
Gabor小波变换和希尔伯特变换研究海马区癫痫发作间期尖波对theta振荡能量特性的影响
Effect of the interictal spike and waves of epileptic seizure on theta oscillation in hippocampal CA1: A Gabor wavelet and Hilbert transform study
摘要
Abstract
BACKGROUND: Theta oscillation is a representative characteristic of neural activity in hippocampus and serves as the starting point for the study of epilepsy and cognition in micro-ways.OBJECTIVE: To investigate the effects of the interictal spike and waves of epileptic seizure on theta oscillation in hippocampal CA1.METHODS: The iEEG data of 8 epileptic rats and 10 patients from School of Medicine, Mediterranean University, Marseilles,France were collected, and their corresponding iEEG data without spike and waves as controls. Gabor wavelet and Hilbert transform were used for extraction of the power of theta oscillation before and after the spike waves. The outcomes of Gabor wavelet and Hilbert transform were compared.RESULTS AND CONCLUSION: Dynamic characteristics of theta power in epilepsy group: Epileptic interictal spike and waves weaken the theta oscillation power, but after a long period of spike and waves, theta oscillation power recovered. It is speculated that the brain's default network connection strength is affected by status epilepticus and may be weakened. However, the weakening of the default network is a pathological basis of cognitive decline.关键词
发作间期尖波/Theta振荡/认知/能量/海马/癫痫/Gabor小波变换/希尔伯特变换分类
基础医学引用本文复制引用
董国亚,陈小刚,周欣花,李文文,葛曼玲..Gabor小波变换和希尔伯特变换研究海马区癫痫发作间期尖波对theta振荡能量特性的影响[J].中国组织工程研究与临床康复,2011,15(13):2403-2407,5.基金项目
河北省自然科学基金项目(E2009000062,E2010000053). （E2009000062,E2010000053）
