中国药理学通报2011，Vol.27Issue(5)：597-600,4.DOI:10.3969/j.issn.1001-1978.2011.05.002
活性氧与内质网应激
ROS and endoplasmic reticulum stress
摘要
Abstract
The endoplasmic reticulum( ER ) is a major site for protein processing and Ca2+ storage and it is extremely sensitive to the stress. In the state of dysfunction, unfolded or misfolded protein accumulation and Ca2+ disbalance occur, known as endoplasmic reticulum stress ( ERS ). Reactive oxygen species ( ROS ), as a second messenger plays an important role in the regulation of biological function in cells. Intracellular changes in redox state promote the generation of ROS and the activation of apoptosis inducing factor, leading to apoptosis which in turn exacerbate the intracellular redox state change. Recent studies have found that intracellular redox changes in the level of ERS mediated apoptosis assumes an important role in the process, and it is speculated that ROS is the upstream signal molecule in ERS-mediated apoptosis pathway. This paper provides a review of the relationship between ROS and ERS.关键词
活性氧/内质网应激/未折叠蛋白反应/钙/细胞凋亡/氧化还原分类
医药卫生引用本文复制引用
周映彤,肖洪彬,毕明刚..活性氧与内质网应激[J].中国药理学通报,2011,27(5):597-600,4.基金项目
国家自然科学基金资助项目(No 30873090) （No 30873090）
