摘要
Abstract
Objective To investigate the effect of plasma exchange in the treatment of patients with severe hepatitis by ob
serving hepatic biochemical markers before and 72 hours after treatment. Methods Retrospective analysis was used in
hepatic biochemical markers,including TBIL, ALT, AST .TBA , GGT,LOH, HBDH ,CHE, TP, ALB,CHOL, TG , K+ , PT ,
APTT and INR of 108 patients with severe hepatitis before and 72 hours after treatment. Results The levels of most bep
atic biochemical markers in patients with severe hepatitis 72 hours after treatment,including TBIL, ALT, AST GGT,
LDH, HBDH, PT, APTT and INR were lower than those before treatment (P＜ 0.01). In addition , TP,CHOL, TG,CHE,
ALB and K+ were higher in patients with severe hepatitis 72 hours after treatment (P＜0. 01,P＜0. 05). After further
analytsis found TBIL , ALT ,AST,TBA,CHOL,PT (s) and INR might be useful in measurement of plasma exchang ,howev
er,other markers still needed be verified. All the 108 patients received 222 plasma exchang,of which 39 patients received
one plasma exchange,36 received 2,21 received 3,12 received 4. Also found that the earlier patients received plasma ex
change,the longer survival rates they might be have. Therefore concluded that patients should receive plasma exchange in
the early time. Conclusion Plasma exchange can improve levels of hepatic biochemical markers in patients with severe
hepatitis and provide opportunities for revive of hepatic function and liver cells. In addition,plasma exchange could become
major means for patients with severe hepatitis to relieve their conditions and provide conditions for liver-transparent opera
tion.关键词
血浆置换/重型病毒性肝炎/肝功能分类
医药卫生
