疑难病杂志2011，Vol.10Issue(5)：325-327,3.DOI:10.3969/j.issn.1671-6450.2011.05.001
阿托伐他汀对原发性高血压左室肥厚患者血浆妊娠相关蛋白-A的影响
The influence of atorvastatin on pregnancy associated plasma protein-A in essential hypertension patients with left ventricular hypertrophy
汪念东 1黄文胜 1范剑峰 1王安才 2汤圣兴1
作者信息
- 1. 246100,安徽省安庆市,海军安庆医院心血管内科
- 2. 241000,安徽省芜湖市,皖南医学院戈矶山医院老年医学内科
- 折叠
摘要
Abstract
Objective To investigate the relationship between pregnancy associated plasma protein-A( PAPP-A ) and essential hypertension ( EH ) patients with left ventricular hypertrophy ( LVH ), and interventional effect of atorvastatin on the inflammatory factors. Methods 49 patients with EH underwent echocardiography examination to determine the inter ventricular septum thickness ( IVST ), left ventricular posterior wall thickness ( LVPWT ) and left ventricular diastolic diameter ( LVDD ), also calculate the left ventricular mass index ( LVMI ). These patients then divided into LVH group and non LVH group according to the diagnostic criteria of left ventricular hypertrophy . Both the LVH group and non LVH group were treated with atorvastatin. The level of PPAP-A pre-and post-treatment were detected by double antibody sandwich Enzyme linked immunosorbent assay ( ELISA ). Results The level of PAPP-A, IVST, LVPWT and LVMI were higher in the LVH group than non LVH group before treatment( P ＜ 0.05 ). After treatment, the level of PAPP-A, LVMI, IVST and LVPWT were decreased obviously compared with pre treatment, but still higher than control group ( all P ＜ 0.05 ). The Pearson analysis shows that PAPP-A and LVMI was closely correlated( r= 0.547, P ＜ 0.05 ). Conclusion The level of PAPP-A were higher in the LVH group than non LVH. PAPP-A and LVMI were positively correlated. Atorvastatin can reduce the level of PAPP-A and reverse myocardial remodel by inhibiting inflammatory factors.关键词
高血压,原发性/左室肥厚/妊娠相关蛋白-A/阿托伐他汀引用本文复制引用
汪念东,黄文胜,范剑峰,王安才,汤圣兴..阿托伐他汀对原发性高血压左室肥厚患者血浆妊娠相关蛋白-A的影响[J].疑难病杂志,2011,10(5):325-327,3.
