西南国防医药2011，Vol.21Issue(5)：479-481,3.DOI:10.3969/j.issn.1004-0188.2011.05.005
富血小板血浆在组织工程骨成骨中的作用研究
Role of platelet-rich plasma in osteogenesis of tissue engineering bone
摘要
Abstract
Objective To explore the role of autologous platelet - rich plasma ( PRP )in the repair of bone defect. Methods Autologous PRP from New Zealand white rabbits were prepared, and a traumatic model of bone defect was established at the same time. Animals were randomly divided into three groups according to the material transplanted into bone defect site. Group A ( experimental group )was added with PRP + bovine thrombin + hydroxyapatite( HA ), group B ( control group )with whole blood + bovine thrombin + HA,and group C ( blank group )without any treatment except the suture of surrounding soft tissues. The progress of osteogenesis in each group was respectively observed in 2,4 and 8 w after transplantation. Results 2 w after transplantation,no obvious osteogenesis was found in the three groups.4 w later, there was a little new bone in group A and B,and group A was better than group B;only a few connective tissues were found in group C. 8 w later,bone defect was almost repaired in group A and B, whereas group C displayed a poor repair. The new bone in group A was more mature than that in group B. Conclusion Based on the HA effects, PRP can further accelerate local new bone formation and maturation during the repair of bone defect.关键词
富血小板血浆/骨缺损/修复/组织工程分类
医药卫生引用本文复制引用
羊书勇,金芳,张建设,郑维银,李晨军,朱宏卫,李焰..富血小板血浆在组织工程骨成骨中的作用研究[J].西南国防医药,2011,21(5):479-481,3.基金项目
成都军区总医院院管课题(07Y01) （07Y01）
