广西医学2011，Vol.33Issue(3)：257-260,4.
精子DNA损伤对体外受精-胚胎移植结局的影响
Effect of Sperm DNA Damage on the Outcome of In Vitro Fertilization-embryo Transfer
摘要
Abstract
Objective To explore the effect of sperm DNA damage on the outcome of in vitro fertilization-embryo transfer (IVF-ET ). Methods The DNA fragmentation of 51 infertile couples undergoing primary IVF-ET was detected by the sperm chromatin dispersion( SCD )test. The pregnancy rate was observed the first day after IVF-ET,and the transgene situation was observed on the third day. Results The negative correlation of fertilization rate , zygote transgene rate,2PN transgene rate with sperm DNA fracture index( DFI )were found( P ＜0. 05 ),and but no correlation was found with optimal embryo rate and 2PN transgene rate( P ＞0. 05 ). Conclusion The damage of sperm DNA has an effect on the outcome of IVF.The fertilization rate of IVF decreases as the DFI of sperms increase,which has an effect on the development of fertilized eggs'cleavage and embryos. Sperm DNA integrity may be an objective indicator to predict the effect of IVF.关键词
不育症/精子DNA损伤/辅助生殖技术/体外受精分类
医药卫生引用本文复制引用
李娜,江莉..精子DNA损伤对体外受精-胚胎移植结局的影响[J].广西医学,2011,33(3):257-260,4.基金项目
广西科学基金(桂科青0447034) （桂科青0447034）
