广西医学2011，Vol.33Issue(3)：270-273,4.
心脏停搏与不停搏心内手术体外循环对凝血功能影响的研究
Comparison of the Effects of Arresting-heart Surgery and Beating-heart Surgery during Cardiopulmonary Bypass on Blood Coagulation
摘要
Abstract
Objective To compare the effects of arresting-heart surgery and beating-heart surgery during cardiopulmonary bypass( CPB )on patients′ blood coagulation. Methods 50 patients with heart disease were divided into beating-heart surgery group( n = 25 )and arresting-heart surgery group( n = 25 ). The changes of prothrombin time ( PT ),activated partial thromboplastin time( APTT ), thrombin time( TT ), fibrinogen( FIB ), D-dimer( D-D )levels,platelet count( PLT ), plasma free Ca2 + , activated prothrombin time( ACT )before skin incision( T1 ), 10 minutes after heparin neutralization by protamine( T2 )and closed chest( T3 )3 -5 hours after operation( T4 )were detected, the amount of postoperative thoracic drainage at 24 hours and homologous blood during and after operation were recorded.Results The values of PT,APTT,TT,FIB,D-D,PLT count,plasma free Ca2+ and ACT at each time point were not statistically significant between the two groups( P ＞ 0.05 ). The amount of homologous blood beating-heart surgery group was significantly less than that of arresting-heart surgery group( P ＜ 0.05 ). The amount of postoperative thoracic drainage at 24 hours was not statistically significant between the two groups( P ＞ 0.05 ). Conclusion Compared with hypothemfic arresting-heart surgery, mild hypothemfia beating-heart after cardiopulmonary bypass does not increase blood clotting disorder. Mild hypothermia beating-heart in open heart surgery with cardiopulmonary bypass can be obviously protected platelet and reduced blood using.关键词
心脏不停搏/凝血功能/体外循环Key words
Beating-heart/Blood coagulation/Cardiopulmonary bypass分类
医药卫生引用本文复制引用
银世杰,黄海清,彭劲松..心脏停搏与不停搏心内手术体外循环对凝血功能影响的研究[J].广西医学,2011,33(3):270-273,4.基金项目
广西医药卫生科学研究基金(桂卫科Z2004141) （桂卫科Z2004141）
广西2010年研究生教育创新计划资助项目 （）
