摘要
Abstract
Objective It's to study the effects of Chitosan on anti-scarring in rabbits' glaucoma filtering surgery model. Methods Healthy adult rabbits were randomly divided into three groups named A, B, and C. Group A, as experiment, was injected Chitosan 2. 5％ in the surgery part. Group B was surgery control group, while Group C was normal control group. Glaucoma filtering surgery was conducted both on the Group A and Group B. The changes of intraocular pressure, the amounts of fibroblast cells, and the situation of scar forming were observed and recorded after the surgery in lw,2w, 4w and 12w respectively. Results As far as intraocular pressure is concerned, Significant differences exist among the three groups after surgery ( P＜ 0. 01 ). Amounts of fibroblast cells in the filtering passage in Group A, whic:h could he examined under high power field, were obviously different from those in Group B after surgery 1 week, 2 weeks and 12 weeks P ＜ 0. 05 ). Conclusion Chitosan, when jointly used in the glaucoma filtering surgery, has some certain effect. It could inhibit fibrous proliferating, help to form anti-scarring, and decrease intraocular pressure perpetually.关键词
壳聚糖/青光眼滤过手术/成纤维细胞
