临床与实验病理学杂志2011，Vol.27Issue(4)：388-392,5.
腘窝恶性骨化性纤维黏液样肿瘤并发肺鳞状细胞癌的临床病理学观察
Clinicopathological features of popliteal malignant ossifying fibromyxoid tumor with pulmonary squamous cell carcinoma
毛荣军 1李启明 1房惠琼 1樊长姝1
作者信息
- 1. 广州中医药大学附属佛山市中医院病理科,528300
- 折叠
摘要
Abstract
Purpose To study the clinicopathological features and differential diagnosis of popliteal malignant ossifying fibromyxoid tumor( MOFT )with pulmonary squamous cell carcinoma( PSCC ). Methods A 58-year-old female of popliteal MOFT with PSCC was studied hy imaging, light microscopy and immunohistochemistry. Results X-ray revealed a clear oval mass with a large number of punctiform or sheeted irregular calcification and ossification shadow in the left medial popliteal fossa. One year late, CT scan revealed multiple masses in right lung and the patient was given electronic bronchoscopic examination and biopsy. Microscopically, the popliteal tumor tissue was composed of metaplastic bone tissue and soft tissue lesion. The metaplastic bone extended from the periphery to the central portion and the center of the tumor had much more of mature bone in the fibromyxoid stroma. Non-ossification areas were formed of fihromyxoid matrix with local hyalinization and round. oval to spindle tumor cells. A little of cartilage-like matrix and cartilage lacuna-like structure was seen in some areas. The areas with high cellularity revealed less fibromyxoid matrix between and around the tumor cells arranged in solid, nodular, linear and mesh-like patterns with high nuclear grade and mitotic activity ranged from 40 t0 60 MF/50 HPF. Some tumor cells around the blood vessels showed the cuffing appearance with grid-like or daisy-type arrangement. Focal capsular and vascular space invasion were seen without necrosis. The tumor cells from lung biopsy were confirmed as PSCC. Immunophenotyping showed the popliteal tumor cells were strongly positive for vimentin, CD56 , CD99 and NSE, and focally positive for CD34, Bcl2 and a-SMA. According to the morphological and immunohistochemical results with medical history it was made a diagnosis of popliteal MOFT with PSCC. Conclusions MOFT is a very uncommon and unique soft tissue tumor of uncertain histogenesis with characteristic imaging and histological features. There are many tumors needed to be distinguished from MOFT. MOFT complicated with PSCC is much rare.关键词
软组织肿瘤/骨化性纤维黏液样肿瘤/肺肿瘤/免疫组织化学/鉴别诊断分类
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毛荣军,李启明,房惠琼,樊长姝..腘窝恶性骨化性纤维黏液样肿瘤并发肺鳞状细胞癌的临床病理学观察[J].临床与实验病理学杂志,2011,27(4):388-392,5.
