临床与实验病理学杂志2011，Vol.27Issue(4)：393-395,399,4.
APCMin/+结直肠癌癌前病变小鼠模型的生物学特性
C57BL/6J-APCMin/+:a mouse model of precancerosis of colorectal cancer
摘要
Abstract
Purpose To describe biological features of C57BL/6J_APCMin/+ mice. Methods APCMin/+ mice were maintained under specific pathogen free conditions. The number and size of intestinal polyps were assessed at different age point. Pathological changes of polyps were confirmed by HE staining. The gene expression in WNT signaling pathways was determined by immunohistochemistry. Results Polyps emerged at approximately 6 weeks age and most mice died at 24 weeks age. Polyp hurden continuously increased hut polyp number of small intestine had no more increase from the age of 9 weeks t0 24 weeks. The oncogene of cyclinD1 was activated after the nucleic localization of β-catenin in adenomas. Conclusion APCMin/+ mice is a good mouse model for the study of early stage of colorectal cancer.关键词
结直肠肿瘤/APCMin/+小鼠/腺瘤/病理变化分类
医药卫生引用本文复制引用
叶志金,郑力,亓翠玲,张敏,唐富天,王尽淘,耿建国,王丽京..APCMin/+结直肠癌癌前病变小鼠模型的生物学特性[J].临床与实验病理学杂志,2011,27(4):393-395,399,4.基金项目
国家自然科学基金(30871304) （30871304）
国家科技部"973"(国家重点基础研究发展计划 2010CB529702) （国家重点基础研究发展计划 2010CB529702）
