中国当代儿科杂志2011，Vol.13Issue(2)：119-122,4.
血清胱抑素C浓度测定对病毒性脑炎患儿肾功能损害的诊断价值
Diagnostic value of serum Cystatin C in renal function impairments in children with viral encephalitis
阮毅燕 1冯军坛 1黄章琼 1秦伟玲 1牟静飞1
作者信息
- 1. 广西妇幼保健院/广西儿童医院儿科,广西,南宁,530003
- 折叠
摘要
Abstract
Objective To study the value of serum Cystatin C (Cyst C) in the evaluation of glomerular filtration function in children with viral encephalitis. Methods Serum levels of Cyst C, urea nitrogen (BUN) and creatinine (Cr) were measured in 92 children with viral encephalitis and in 50 healthy children as a control group. According to glomerular filtration rate (GFR), the encephalitis group was subdivided into normal renal function, renal insufficiency in the compensatory or decompensatory stage, and renal failure/end-stage groups. Results Serum levels of Cyst C, BUN and Cr in the encephalitis group increased and GFR decreased significantly compared with those in the control group (P ＜0.01 ).With the decline of renal function, GFR decreased and serum levels of Cyst C, BUN and Cr increased 8radually. Serum levels of Cyst C and GFR were significantly different among the encephaitis subgroups ( P ＜ 0.01 ). For serum levels of BUN and Cr, there were significant differences among the subgroups except between the normal renal function and the compensatory renal insufficiency groups. Serum Cyst C level was positively correlated with serum BUN and Cr levels, and negatively correlated with GFR. Conclusions The children with viral encephalitis have different degrees of renal impairments. Cyst C appears to be superior to BUN and Cr as a marker for the evaluation of glomerular filtration function.Measurement of serum Cyst C levels is very valuable in renal function monitoring in children with viral encephalitis.关键词
病毒性脑炎/肾功能损害/胱抑素C/儿童分类
医药卫生引用本文复制引用
阮毅燕,冯军坛,黄章琼,秦伟玲,牟静飞..血清胱抑素C浓度测定对病毒性脑炎患儿肾功能损害的诊断价值[J].中国当代儿科杂志,2011,13(2):119-122,4.
