中国全科医学2011，Vol.14Issue(13)：1451-1453,1458,4.
联合应用莫西沙星或左氧氟沙星治疗耐多药肺结核疗效研究
Effects of Anti-Tuberculosis Containing with Moxifloxacin or Levofloxacin on Multidrug Resistant Pulmonary Tuberculosis
梁丽丽 1刘新 1马芸2
作者信息
- 1. 450008,河南省郑州市,河南省胸科医院
- 2. 河南省人民医院
- 折叠
摘要
Abstract
Objective To investigate the effect of moxifloxacin on multidrug resistant pulmonary tuberculosis ( MDT -PTB ), and to compare with that of levofloxacin, in order to assess its efficacy and safety. Methods Totally 82 patients with MDR - PTB. who were confirmed by tuberculosis bacterium cultivation in our hospital from January 2007 to December 2008,were randomly divided into two group. Thr patients in the trial group ( n = 46 ) were given 3MPaL222ThPAk/6MPaL222Th/9MPaL222. The patients in the control group ( n = 36 ) were given the similar treatment only with one exception of substitution of levofloxacin for moxifloxacin. Results There were 35 patients in the trial group completed the course and 30 in the control group completed the course. After the end of treatment. in the two groups the rates of sputum negative conversion were 82. 9％ ( 29/35 ) and 60. 0％ (18/30 ) respectively ( P ＜0. 05 ); the rates of focal efficacy were 91. 4％ ( 32/35 ) and 80. 0％ ( 24/30 ) respectively ( P ＞0. 05 ); and the rates of cavity closure were 65. 8％ ( 25/38 ) and 37. 5％ ( 9/24 ) respectively ( P ＜0. 05 ). The difference of effect between the two groups showed statistical significance ( P ＜ 0. 05 ). Conclusion The efficacy and safety of moxifloxacin are superior to those of levofloxacin , so moxifloxacin can serve as the main drug for treatment of MDR - PTB in compound therapy combining with fluoroquinolones.关键词
结核,肺/耐多药/莫西沙星分类
医药卫生引用本文复制引用
梁丽丽,刘新,马芸..联合应用莫西沙星或左氧氟沙星治疗耐多药肺结核疗效研究[J].中国全科医学,2011,14(13):1451-1453,1458,4.
