中国当代儿科杂志2011，Vol.13Issue(2)：101-103,3.
儿童急性淋巴细胞白血病血清IGF-1和IGFBP-3表达变化及其意义
Serum levels of insulin-like growth factor-1 and growth factor binding protein-3 in children with acute lymphocytic leukemia
摘要
Abstract
Objective To study serum levels and clinical significance of insulin-like growth factor-1 ( IGF-1 ) and growth factor binding protein 3 ( IGFBP-3 ) in children with acute lymphocytic leukemia (ALL). Methods Serum samples were obtained from 36 children with ALL before treatment and 6 months after complete remission. Thirty children with surgical diseases severed as the control group. Serum IGF-1 levels were measured using radioimmunoassay (RIA). Serum IGFBP-3 levels were measured using immunoradioassays ( IRMA ). Results Serum levels of IGF-1 and IGFBP-3 in the ALL group were 19 ±4 ng/mL and 1216 ± 132 ng/mL, respectively before treatment, which were lower than those in the control group (32 ± 3 ng/mL and 2104 ± 191 ng/mL respectively) (P ＜ 0.01 ). Serum levels of IGF-1 and IGFBP-3 in the ALL group increased to 30 ±3 ng/mL and 1941±164 ng/mL respectively 6 months after complete remission, which were significantly higher than those before treatment ( P ＜ 0.01 ) and were similar to the levels of the control group. Conclusions Serum levels of IGF-1 and IGFBP-3 are reduced in children with ALL, but increase significantly after complete remission, suggesting that IGF-1 and IGFBP-3 might serve as useful markers for the diagnosis and evaluation of therapeutic effects of childhood ALL.关键词
胰岛素样生长因子/急性淋巴细胞白血病/儿童分类
医药卫生引用本文复制引用
赵东菊,张文林,石太新..儿童急性淋巴细胞白血病血清IGF-1和IGFBP-3表达变化及其意义[J].中国当代儿科杂志,2011,13(2):101-103,3.基金项目
河南省教育厅科技攻关计划项目(200510472005). （200510472005）
