傅浩 1万林林 1杨灵 1袁传平 1刘小红 1邹瑜斌1
作者信息
- 1. 338025,江西省新余市人民医院肿瘤科
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of temozolomide ( TMZ ) combined with concomitant 3 - Dimension conformal radiotherapy ( 3D - CRT ) in treatment of postoperative patients with malignant intracranial glioma. Methods 28 postoperative patients with malignant glioma confirmed by pathology were randomly divided into two groups ( control group and treatment group ), with each group 14 cases. The patients of treatment group received four to six cycles of temozolomide combined with 3D - CRT, with each cycle 28 days. The control group cases only received radiotherapy. The approach and dose of radiotherapy for each group were the same. After treatment, all patients followed up periodically. The efficacy, median recurrent time, survival rate, life quality and medicine safety were analyzed. Results Whole - brain CT or MRI showed that in treatment group, with 3 cases completely relieved, 4 cases partly relieved, 5 cases stahilized, 2 cases aggravated. In control group , with 2 cases completely relieved , 2 cases partly relieved, 7 cases stabilized and 3 cases aggravated. There was no statistically significant difference between the two groups ( P ＞0. 05 ). Median recurrent time was 21 months in treatment group and 17 months in control group ( P ＜ 0. 05 ); The 1, 2, 3 years survival rates were 85. 7％ ( 12/14 ), 78. 6％ ( 11/14 ) and 57. 1％ ( 8/14 ) in treatment group and 71. 4％ ( 10/14 ), 35. 7％ ( 5/14 ) and 14. 3％ ( 2/14 ) in the control group. There were significant differences in 2, 3 years survival rates and median re.current time between the two groups ( P ＜ 0. 05 ). The main side effects in treatment group were nausea, vomiting, myelosuppression and headache ( grade Ⅰ ～Ⅱ ), the incidence was low.Symptomatic treatment for these side effects did not affect the treatment of glioma. The improvement of life quality in treatment group was significantly better than that of control group. Conclusion Three - dimension conformal radiotherapy combined with temozolomide is not more effective than radiotherapy alone in postoperative malignant glioma in the near future, but can improve the 2, 3 years survival rates with slight side effects , and it can significantly improve the quality of life.关键词
恶性脑胶质瘤/三维适形放疗/替莫唑胺/化学疗法分类
医药卫生
