中国全科医学2011，Vol.14Issue(14)：1572-1574,3.
氟伐他汀对心肌细胞凋亡的调控作用及其可能机制研究
Research on Regulation of Cardiomyocytes Apoptosis by Fluvastatin and Its Mechanisms
摘要
Abstract
Objective To study the regulation of apoptosis of cardiomyocytes by Fluvastatin and its mechanism based on the cell model of rat embryo - myocardial cells. Methods The cell viability was observed by MTT assay , and the cell apoptosis was examined by flow cytometry. The expression of TGF - β1 and its receptor were examined by real time RT - PCR and western blot. Results Fluvastatin could reduce the viability of the H9c2 cells by concentration - dependent method. Treatment of H9c2 cells with 10 μM fluvastatin could induce the apoptosis of the cells, and 4 days after treatment with 10 μM fluvastatin,the apoptosis rate of H9c2 cells reached 54. 9％ . Fluvastatin could up regulate the expression of TβⅡ mRNA and protein but could not significantly up regulate the expression of TGF - β1 or TβR I . Conclusion Fluvastatin can induce the apoptosis of H9c2 cells and this induction may relate to the up - regulation of TβR IⅡ .关键词
氟伐他汀/细胞凋亡/肌细胞,心脏/受体,转化生长因子β分类
医药卫生引用本文复制引用
李宗斌,朱梅,郑小琴,文毅,李泱,朱庆磊,王士雯..氟伐他汀对心肌细胞凋亡的调控作用及其可能机制研究[J].中国全科医学,2011,14(14):1572-1574,3.基金项目
国家自然科学基金(30700305,81000302) （30700305,81000302）
北京市科技新星计划(2008A064) （2008A064）
军队十五科技项目 (01MA104) （01MA104）
中国博士后基金(20080431356) （20080431356）
