重庆医学2011，Vol.40Issue(14)：1356-1357,封2,3.DOI:10.3969/j.issn.1671-8348.2011.14.003
慢性酗酒大鼠血清神经元特异性烯醇化酶的表达与脑损伤关系的研究
Study on expression of serum NSE in chronic alcoholism rats and its relationship with brain injury
摘要
Abstract
Objective To explore the expression of serum NSE of chronic alcoholism rats and its relationship with brain injury.Methods The concentration of serum NSF of high concentration alcoholism rats group,middle concentration alcoholism rats group and drinking water group rats were measued with RIA,and the relationship between brain injury with them in different groups were analysed.Results The concentration of serum NSE in the high and middle concentration alcoholism rats groups were significantly higher than that in the drink water group(P＜0.01) ,at the same time, which was higher in the high concentration alcoholism rats group than that in the middle concentration group.The concentration of serum NSE became higher in the high and middle concentration alcoholism rats groups when they drunk longger time(P＜0.05) ,which had no obvious changes in drinking water group(P＞0.05).The degree of brain injury was the same as the concentration of serum NSE, which was observed from structure of brain tissue.Conclusion The concentration of serum NSE became higher as the rats were drinked chronically,and which became more clear as the concentration of wine was higher or the rats were drinked longer time.The concentration of serum NSE was the same as the degree of brain injury,from whose change we can estimate the degree of brain injury flexiblely.关键词
酒精中毒/磷酸丙酮酸水合酶/脑损伤引用本文复制引用
汪家文,刘应时,于晓军,刘芳,刘艳伟,陈小艳..慢性酗酒大鼠血清神经元特异性烯醇化酶的表达与脑损伤关系的研究[J].重庆医学,2011,40(14):1356-1357,封2,3.基金项目
国家自然科学基金资助项目(30772458). （30772458）
