肿瘤预防与治疗2011，Vol.24Issue(3)：153-156,4.DOI:10.3969/j.issn.1674-0904.2011.03.005
Apogossypolone对人前列腺癌LNCaP移植瘤的生长抑制作用
Inhibitory Effects of Apogossypolone on Subcutaneous Implants of Human LNCaP Prostatic Carcinoma Cells
陈要臻 1陈晨 1黄晓锋 2穆士杰 1胡兴斌 1安群星 1张献清1
作者信息
- 1. 第四军医大学西京医院输血科,西安,710032
- 2. 第四军医大学中心实验室,西安,710032
- 折叠
摘要
Abstract
Objective : To investigate the inhibitory effect of apogossypolone( ApoG2 ) on subcutaneous implants of human LNCaP prostatic carcinoma cells , and explore its mechanism. Methods : To establish human LNCaP prostatic carcinoma cell line subcutaneous xenograft models and observe the inhibitory effect of ApoG2 on the tumor model. Immunohistochemistry was employed to observe the expression of Bcl- 2, PCNA. CD31 , caspase- 3 and- 8 in tumor tissues. The microvessel density was calculated. Results :ApoG2 could obviously inhibit the growth of subcutaneous prostatic carcinoma implant. ApoG2 decreased the expression of PCNA and CD31 , and increased the expression of caspases-3 ,-8 in tumor tissues. Conclusion : ApoG2 has an inhibitory effect on prostatic carcinoma implants.关键词
Apogossypolone/前列腺癌/人前列腺癌LNCaP细胞系/移植瘤分类
医药卫生引用本文复制引用
陈要臻,陈晨,黄晓锋,穆士杰,胡兴斌,安群星,张献清..Apogossypolone对人前列腺癌LNCaP移植瘤的生长抑制作用[J].肿瘤预防与治疗,2011,24(3):153-156,4.
