针灸临床杂志2011，Vol.27Issue(2)：52-56,5.
正交设计法筛选"醒脑开窍"内关穴最优针刺参数方案的研究
The Study on Optimum Acupuncture Parameter for Neiguan point of Xingnao Kaiqiao Needling Method by Orthogonal Design
摘要
Abstract
Objective:To probe the optimum stimulation parameter for Neiguan point of Xingnao Kaiqiao needling method. Methods:The rat model of middle cerebral artery obstruction (MCAO) was induced and"Neiguan" was stimulated by 9 acupuncture parameters combined with two factors at 3 levels, i. e. frequency 1,2,3 times/second,and needling duration 5s, 60s, 180s. The effects of acupuncture at "Neiguan" with 9 different acupuncture parameters on cerebral blood flow(CBF) and the number of nerve cell necrosis in the MCAO rat were investigated by orthogonal test. Results:Acupuncture efficacy was influenced by acupuncture frequency,acupuncture duration and their interaction. According to the different indicators, frequency, time, the effect of their interaction was different. Conclusion:By Xingnao Kaiqiao needling method,acupuncture at" Neiguan"with middle frequency and short duration could get the best acupuncture efficacy, which was the optimum stimulation parameters for" Neiguan".关键词
正交设计法/内关/针刺参数/大鼠/脑缺血分类
医药卫生引用本文复制引用
贺妮娜,樊小农,王舒,石学敏..正交设计法筛选"醒脑开窍"内关穴最优针刺参数方案的研究[J].针灸临床杂志,2011,27(2):52-56,5.基金项目
国家重点基础研究发展计划("973计划")资助,编号:2006CB504504,2010CB530506 （"973计划"）
天津市科技攻关重大科技项目,编号:05YFGDSF02300. （）
