浙江医学2011，Vol.33Issue(4)：511-513,3.
脑出血患者急性期血清转铁蛋白及铁蛋白水平的动态变化
Dynamic changes of serum transferrin and ferritin levels in patients with acute intracerebral hemorrhage
魏瑞理 1金露 1孔慧梅 1邹明 1林燕 1陈卫东 1王小同1
作者信息
- 1. 325027,温州医学院附属第二医院神经内科
- 折叠
摘要
Abstract
Objective To measure serum transferrin (Tf) and ferritin (sFt)levels in patients with acute intracerebral hemorrhage and to investigate its clinical significance.Methods Serum Tfand sFt levels were measured in 35 patients with acute intracerebral hemorrhage during different phases (within 24 h, at 3, 7,14 and 21d after the onset of disease) and 30 healthy subjects (control group).The correlation of Tf and sFt levels with cerebralhemorrhage volume and NIHSS score were analyzed.Results Serum Tf levels increased rapidly (P＜0.05) after the onset of acute intracerebral hemorrhage and reached the peak at d3,then decreased gradually and returned to normal level at d14.Serum ferritin level did not changed significantly during the first 2 days and then increased gradually, reached the peak at d7 and kept high level at d21 (P＜0.05).Intracerebral hemorrhage volume and NIHSS scores were positively correlated with serum ferritin levels on 3d (r= 0.654、0.514, P＜0.01) ,but not with serum Tf levels at 24h.Conclusion Serum transferrin and ferritin are involved in the pathophysiological process of intracerebral hemorrhage,which may be related to the removal of excess iron after ICH.关键词
脑出血/转铁蛋白/铁蛋白/铁离子引用本文复制引用
魏瑞理,金露,孔慧梅,邹明,林燕,陈卫东,王小同..脑出血患者急性期血清转铁蛋白及铁蛋白水平的动态变化[J].浙江医学,2011,33(4):511-513,3.
