布洛芬缓释片的制备及其体外释放度考察OACSCDCSTPCD
Preparation of Ibuprofen Sustained-release Tablet and Its Release Rate in Vitro
目的:研制布洛芬缓释片并建立其体外释放度测定方法.方法:以亲水性凝胶骨架材料羟丙基甲基纤维素制备布洛芬缓释片.采用高效液相色谱法测定其含量,根据<中国药典>2010年版篮法,以磷酸盐缓冲液为溶出介质、转速为150 r·min-1测定3批样品的体外释放度,进行批闻重现性和同一批样品的均一性(1、3、6、8h)考察.结果:所制3批缓释片在8 h内释放基本完成,批间重现性良好;同一批样品在1、3、6、8 h各取样时间点,释放度的RSD值分别…查看全部>>
OBJECTIVE: To study and prepare Ibuprofen sustained-release tablets and to establish determination method for release rate of it in vitro. METHODS: Ibuprofen sustained-release tablet was prepared using hydrophilic gel framework material. The content of Ibuprofen sustained release tablets was determined by HPLC. Ac coding to stirring basket method stated in Chinese Pharmacopeia (2010 edition), phosphate buffer solution was used as solvent at rotating speed of…查看全部>>
王平;肖昌录;袁训贤
四川邛崃市医疗中心医院药剂科,成都市,611530四川邛崃市医疗中心医院药剂科,成都市,611530默克雅柏药业(中国)有限公司,中山市,528437
医药卫生
布洛芬缓释片制备体外释放度高效液相色谱法篮法
《中国药房》 2011 (9)
829-831,3
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