中国药房2011，Vol.22Issue(9)：832-833,2.
醋氯芬酸栓的制备及质量控制
Preparation and Quality Control of Aceclofenac Suppository
许谙1
作者信息
- 1. 浙江海宁市人民医院药剂科,海宁市,314400
- 折叠
摘要
Abstract
OBJECTIVE: To prepare Aceclofenac suppository and to establish a method for its quality control. METHODS: The suppository was prepared using aceclofenac as main component and semi-synthetic glyceride as matrix. The content of aceclofenac was determined by HPLC and the stability of suppository was investigated by high-light test, accelerated test and long-term test. RESULTS: The preparation was white-like to faint-yellow suppository. The identification of suppository was in line with the standard. The linear range of aceclofenac was 5.08～30.48 μg·mL-1 (r=0.999 8) with an average recovery of 99.3％. The RSD of intra-day and inter-day was 1.23％ and 1.88％. The stability test of preparation showed indices of it had no change. CONCLUSION: The preparation technology of suppository is simple and feasible, and its quality is stable and controllable.关键词
醋氯芬酸栓/高效液相色谱法/制备/质量控制分类
医药卫生引用本文复制引用
许谙..醋氯芬酸栓的制备及质量控制[J].中国药房,2011,22(9):832-833,2.
