肿瘤防治研究2011，Vol.38Issue(2)：163-166,4.DOI:10.3971/j.issn.1000-8578.2011.02.012
Wnt1、β-catenin、APC和cyclin D1蛋白在胃癌中的表达
Expression of Wnt1,β-catenin, APC and cyclinD1 Proteins in Gastric Carcinoma
摘要
Abstract
Objective To detect the expression of Wnt1,β-catenin, APC and cyclin D1 proteins in human gastric carcinoma.Methods The immunohistochemical staining (LASB) was performed in 45 specimens and normal tissue adjacent to tumor border (＞5cm).Results In 45 cases gastric carcinoma, the positive rates of Wnt1, β-catenin and cyclin D1 were 57.78％, 73.33％ and 51.11％ respectively.In comparison, statistic difference is apparent because of their absence (excluding membrane expression of β-catenin) in normal tissue (P＜0.01 ).However, APC expression is lower in gastric carcinoma than that in normal tissue (53.33％ vs.91.11％).There is marked significance likewise(P ＜0.01 ).The co-expression (Wnt pathway is activated, Wnt + ) rate of Wnt1, β-catenin and cyclin D1 is 44.44％ ,which is much higher than that in normal tissue(P＜0.01 ).Conclusion Wnt1-β-catenin-APC-cyclinD1 signal pathway is abnormal expressed in gastric carcinoma genesis.关键词
Wnt1/β-catenin/APC/cyclin D1/胃癌/免疲组织化学分类
医药卫生引用本文复制引用
韩向春,康金旺,郑力强,左连富..Wnt1、β-catenin、APC和cyclin D1蛋白在胃癌中的表达[J].肿瘤防治研究,2011,38(2):163-166,4.基金项目
张家口市科技攻关计划资助项目(0921111D) （0921111D）
