肿瘤防治研究2011，Vol.38Issue(2)：167-169,3.DOI:10.3971/j.issn.1000-8578.2011.02.013
PDGF-D及其受体在胃癌组织中的表达及意义
Expression and Significance of PDGF-D and Its Receptor in Gastric Carcinoma Tissues
摘要
Abstract
Objective To investigate the correlation between mRNA expression of PDGF-D and PDGFRβ and clinicopathological features in gastric cancer. Methods The reverse transcription-polymerase chain reaction(RT-PCR)technique was used to examine mRNA expression of PDGF-D and PDGFRβ in 58 paired specimens of gastric carcinoma and tissues adjacent carcinoma. Results The positive rates of PDGF-D mRNA and PDGFRβ mRNA(98. 28％,87. 93％ )were higher in gastric cancer tissues than(72. 41 ％, 53. 45％) in tissues adjacent carcinoma respectively. While the positive rate of PDGFRβmRNA was 72. 41 ％, which was positively correlated with PDGF-D(r = 0. 40, P＜0. 05 ).PDGF-D expression was correlated with lymph node metastasis and relapse (P＜0. 05). No correlation was found between PDGF-D and other clinicopathological features of gastric carcinoma (P＞ 0. 05).Conclusion PDGF-D may play a crucial role in carcinogenesis, development, metastasis and relapse of gastric cancer. It can be used as prognostic markers of gastric cancer in clinical practice.关键词
血小板衍生生长因子-D/血小板衍生生长因子受体β/胃癌/反转录聚合酶链反应分类
医药卫生引用本文复制引用
丁苏宁,李莉华,华东,宋明旭,周希科,吴二斌,刘志辉..PDGF-D及其受体在胃癌组织中的表达及意义[J].肿瘤防治研究,2011,38(2):167-169,3.基金项目
无锡市科技局社会发展计划资助项目(CSZ00936) （CSZ00936）
