肿瘤防治研究2011，Vol.38Issue(2)：192-194,3.DOI:10.3971/j.issn.1000-8578.2011.02.019
中晚期宫颈癌三维适形放疗联合同步化疗的临床观察
Clinical Observation of Three Dimension Conformal Radiotherapy with Concurrent Chemoradiotherapy for Middle and Advanced Cervical Cancer
摘要
Abstract
Objective To evaluate the effect and toxic reaction of three dimensional conformable radiotherapy (3D-CRT)after whole pelvic radiotherapy with concurrent chemoradiotherapy on middle and advanced cervical cancer. Methods Sixty-two patients with middle or advanced cervical cancer were divided randomly into 3D-CRT after whole pelvic radiotherapy with concurrent chemoradiotherapy(A group)and afterloading irradiation after whole pelvic radiotherapy with concurrent chemoradiotherapy (B group). After receiving 36～40Gy/20 fractions of external radiation to the whole pelvic, patients in the group A were irradiated by 3-DCRT with the total dose of 66～75Gy. Patients in the group B received 45～50Gy external radiation to the parametrrium, and point A received 30Gy by after loading irradiation (4～7Gy per-fraction, 1 ～2 fractions per week). All patients were given concurrent chemoradiotherapy in the firstweek and the fourth week. Results Effective rate was 96.88 in group A and 76.67％ in group B(P＜0.05). The rates of bone marrow inhibition and long-term complication for the rectum and bladder were significantly lower in group A than in group B(P＜0.05). Conclusion The 3D-CRT after whole pelvic radio-therapy with concurrent chemoradiotherapy for middle and advanced cervical cancer could improve local control rate.关键词
三维适形放疗/中晚期宫颈癌/同步放化疗分类
医药卫生引用本文复制引用
成浩,唐世强..中晚期宫颈癌三维适形放疗联合同步化疗的临床观察[J].肿瘤防治研究,2011,38(2):192-194,3.基金项目
郴州市第一人民医院科研基金资助项目(N2008-053) （N2008-053）
