中国医科大学学报2011，Vol.40Issue(2)：159-161,3.DOI:CNKI:21-1227/R.20110212.0954.016
西洛他唑与尼莫地平联合应用防治蛛网膜下腔出血迟发性脑血管痉挛的疗效
Effects of Cilostazol and Nimodipine Combined Therapy on Delayed Cerebral Vasospasm after Subarachnoid Hemorrhage
王红艳 1戚肪 1胥向红 1王晓强1
作者信息
- 1. 辽宁医学院附属第三医院神经内科,辽宁,锦州,121001
- 折叠
摘要
Abstract
Objective To discuss the clinical effects of cilostazol and nimodipine combined therapy on cerebroval vasospasm (CVS) after subarachnoid hemorrhage (SAH).Methods Totally 210 patients with intracranial SAH were randomly divided into control group and treatment group.The patients in control group were treated with nimodipine 1 mg/h pumping continuously for 14 days.The patients in the treatment group were given nimodipine 1 mg/h pumping continuously and cilostazol 50 mg twice per day for 14 days.Vital signs were monitored continuously in all patients.The clinical data of pre- and post-therapy in the two groups, such as clinical manifestation, the level of consciousness (GCS grade,Hunt & Hess scores),CT,TCD and MRl,were compared.Results There was no significant difference in GCS grade, Hunt & Hess, Fisher pre-therapy between the two groups ( P ＞ 0.05 ).The incidence of cerebral infarction in the treatment group [11 (10.5％)]was lower than that of the control group [23 (21.9％)](P＜ 0.05).TCD showed the mean blood flow of median cerebral artery (MCA) was 115.6±12.5 cm/s in control group and 112.5±10.9 cm/s in the treatment group ( 1 day after hemorrhage),and there was no difference between the two groups (P＞ 0.05).The mean blood flow of MCA on 3,7 and 14 days after hemorrhage in the treatment group was obviously slower than those of the control group ( P ＜ 0.05 ).The effective rate of the treatment group ( 74.3％ ) was higher than that of the control group ( 60.0％ )( P ＜ 0.05 ).Conclusion The combined therapy of cilostazol and nimodipine was effective for delayed CVS after SAH.关键词
蛛网膜下腔出血/迟发性脑血管痉挛/治疗分类
医药卫生引用本文复制引用
王红艳,戚肪,胥向红,王晓强..西洛他唑与尼莫地平联合应用防治蛛网膜下腔出血迟发性脑血管痉挛的疗效[J].中国医科大学学报,2011,40(2):159-161,3.
