中国医科大学学报2011，Vol.40Issue(2)：166-171,6.DOI:CNKI:21-1227/R.20110212.0954.018
SDF-1/CXCR4生物学轴在乳腺癌中的表达及其临床意义
The Expression and Clinical Significance of the SDF-1/CXCR4 Biological Axis in Breast Cancer
宦大为 1林萍 2滕猛 3王巧欢 1张文竹 2张弘2
作者信息
- 1. 沈阳医学院奉天医院病理科,沈阳,110024
- 2. 中国医科大学基础医学院病理教研室,沈阳,110001
- 3. 中国医科大学附属第四医院中心实验室,沈阳,110032
- 折叠
摘要
Abstract
Objective To analyze the clinicopathological significance of ligand SDF-1 and its receptor CXCR4 expression in breast carcinoma,ductal carcinoma in situ and adjacent tissues and clarify the roles of SDF-1/CXCR4 biological axis in the pathogenesis of breast cancer. Methods SDF-1 and CXCR4 protein expression were examined in 80 cases of breast carcinoma, 15 cases of ductal carcinoma in situ and 15 cases of adjacent tissue by immunohistochemistry. SDF-1 and CXCR4 mRNA expression were determined in 40 cases of breast invasive carcinoma, 5 cases of ductal carcinoma in sim and 5 cases of normal tissue adjacent to cancer tissues by RT-PCR. Results The protein and mRNA expreresions of SDF-1 and CXCR4 were different in breast carcinoma and ductal carcinoma in situ,ductal carcinoma in situ and adjacent tissues (P ＜ 0.05 ). The expression of CXCR4 protein was related to lymph node metastasis and breast cancer stage (P ＜0.05). Both protein and mRNA expression of SDF-1 and CXCR4 were positively correlated in breast carcinoma (P ＜ 0.05). Conclusion SDF-1/CXCR4 biological axis might play an important role in promoting breast cancer growth and metastasis.关键词
SDF-1/CXCR4生物学轴/乳腺癌/免疫组化/RT-PCR分类
医药卫生引用本文复制引用
宦大为,林萍,滕猛,王巧欢,张文竹,张弘..SDF-1/CXCR4生物学轴在乳腺癌中的表达及其临床意义[J].中国医科大学学报,2011,40(2):166-171,6.
