中国组织工程研究与临床康复2011，Vol.15Issue(11)：1965-1968,4.DOI:10.3969/j.issn.1673-8225.2011.11.016
长波紫外线照射皮肤成纤维细胞表皮生长因子受体的表达
Influence of ultraviolet light A on epidermal growth factor receptor expression in fibroblasts in vitro
摘要
Abstract
BACKGROUND: Ultraviolet A has a close relationship with skin photoaging, which impact on epidermis and dermis.OBJECTIVE: To explore the influence of ultraviolet A on the epidermal growth factor receptor expression of human skin fibroblasts in vitro.METHODS: Adult's fibroblasts were divided into the control and ultraviolet A irradiation (5, 10, 20 J/cm2) groups. The epidermal growth factor receptor mRNA and protein were detected by real-time PCR and Western blot.RESULTS AND CONCLUSION: The epidermal growth factor receptor mRNA and protein levels had upgraded as the dose of ultraviolet A irradiation increased. It suggests that ultraviolet A can lead to epidermal growth factor receptor expression in fibroblasts.关键词
长波紫外线/光老化/表皮生长因子受体/成纤维细胞/皮肤分类
医药卫生引用本文复制引用
刘垠,刘流,王继华,鲁开化,伍尚敏,杨瑞年,龙庭凤,袁瑞宏..长波紫外线照射皮肤成纤维细胞表皮生长因子受体的表达[J].中国组织工程研究与临床康复,2011,15(11):1965-1968,4.基金项目
云南省自然科学基金面上项目(2004C0047M). （2004C0047M）
