中国组织工程研究与临床康复2011，Vol.15Issue(11)：2006-2008,3.DOI:10.3969/j.issn.1673-8225.2011.11.026
光动力学照射小鼠牙周组织的病理变化
Pathological changes of mouse periodontal tissues following photodynamic therapy
摘要
Abstract
BACKGROUND:Photodynamic therapy (PDT) may have bad effects on oral cavity tissue, so the biological safety evaluation is necessary before Toluidine blue O (TBO)-mediated PDT of dentine caries in clinic.OBJECTIVE:To observe the effects of photosensitization of the TBO-mediated PDT to periodontal tissues in mice.METHODS:Fifty-four mice were randomly divided into nine groups, and were respectively treated with 0 mg/L, 50 mg/L, 100 mg/L TBO with 0, 15, 25min LED illumination. Periodontal tissue slices were taken to observation after treatment of 72 hours.RESULTS AND CONCLUSION:There were no abnormal changes like necrosis, ulcer or hyperplasia happens in the mice gingival,alveolar bone or teeth after light treatment. This indicated that TBO-mediated PDT was safe to the prevention of dental caries,without damaging effect to periodontal tissues adjacent to the teeth.关键词
甲苯胺蓝/二极管激光/光动力学疗法/小鼠/牙周组织/病理分类
医药卫生引用本文复制引用
杜波,蒋琳,刘明方,李苹苹,林居红..光动力学照射小鼠牙周组织的病理变化[J].中国组织工程研究与临床康复,2011,15(11):2006-2008,3.基金项目
重庆市卫生局基金项目项目(2008-2-243),光动力学疗法对人工菌斑生物膜影响的实验研究. （2008-2-243）
