中国组织工程研究与临床康复2011，Vol.15Issue(11)：2051-2054,4.DOI:10.3969/j.issn.1673-8225.2011.11.038
应激动物模型构建方法及效果评价的研究进展
Progress addressing animal stress model construction and effect evaluation
摘要
Abstract
BACKGROUND: People are paying close attention to the relationship between stress and disease. Establishment of animal stress models is the basic for stress research, which is lack of united standard .OBJECTIVE: To introduce animal model construction methods and effect evaluation, in addition, to analyze existing problems during model preparation.METHODS: A computer-based online search was performed using key words of "stress, animal model, murine, and evaluate" for documents on VIP and PuMed from 2000 to 2010. Repetitive papers were excluded.RESULTS AND CONCLUSION: A total of 417 documents were collected, including 115 in Chinese and 302 in English. By reading titles and abstract, 30 papers were included in the final analysis. Currently, various animal stress models are involved, but there is not a unified standard , and the stress degree remains lack of quantizatable index. With rapidly development of neu roscience,molecular biology, and electrophysiology, the stress research is extended into molecular level and integrated network. The wide application of transgenic technology, gene knockout models, and protein depletion provide new approach for study of stress mechanism.关键词
应激/动物模型/鼠/评价/综述文献分类
医药卫生引用本文复制引用
娜琴,程飚,陈阿梅..应激动物模型构建方法及效果评价的研究进展[J].中国组织工程研究与临床康复,2011,15(11):2051-2054,4.基金项目
全军医学科学技术研究"十一五"计划面上项目(08G027). （08G027）
