中国组织工程研究与临床康复2011，Vol.15Issue(11)：1977-1980,4.DOI:10.3969/j.issn.1673-8225.2011.11.019
CD34及CD105两种微血管标记物在瘢痕微血管构筑中的比较
Comparison of two microvessels markers CD34 and CD105 in microvasculature of pathological scars
摘要
Abstract
BACKGROUND: There is not a reliable neovascularization marker for pathological scar. Though CD34 and CD105 are considered to be a credible vascular endothelial cell marker, they have own specially features.OBJECTIVE: The difference between the two microvessels marker CD34 and CD105 in microvasculature of pathological scar.METHODS: Immunohistochemistcal staining for the CD34 and CD105 was performed in normal skin tissue specimens,non-pathological scar tissue specimens, hypertrophic scar tissue specimens and keloid tissue specimens, the internal diameter (ID) of microvessels marked by CD34 and CD105 and the expression area of CD34 and CD105 were measured by image analysis software Moticlmages Advanced 3.2, the morphology and distribution characteristics of mirovessels were analyzed after the photos taken by image acquisition instruments.RESULTS AND CONCLUSION: In all of specimens, the ID of microvessels marked by CD34 and CD105 were (73.14±17.85) μm and (27.91±5.86) μm, respectively, the microvessels marked by CD105 were newer than the microvessels marked by CD34. As an endothelial marker of angiogenesis, CD105 is a more special marker for neovascularization than CD34 in pathological scar,CD105 could be considered to be a credible neovascularization marker.关键词
微血管构筑/CD34/CD105/病理性瘢痕/皮肤分类
医药卫生引用本文复制引用
黄如林,梁杰,夏琼平,黄绮梨,吴志贤..CD34及CD105两种微血管标记物在瘢痕微血管构筑中的比较[J].中国组织工程研究与临床康复,2011,15(11):1977-1980,4.基金项目
广东省自然科学基金项目项目(06028957). （06028957）
