中国组织工程研究与临床康复2011，Vol.15Issue(12)：2146-2148,3.DOI:10.3969/j.issn.1673-8225.2011.12.014
应用生物可降解材料玉米醇溶蛋白制备胃肠道生物黏附控释片
Preparation of gastrointestinal bioadhesive controlled release tablets using biodegradable Zein
摘要
Abstract
BACKGROUND:Gastrointestinal bioadhesive controlled release tablets can extend the residence time of pharmaceutical preparations in gastrointestinal tract, and increase drug bioavailability.OBJECTIVE:To prepare 5-fluorouracil gastrointestinal bioadhesive controlled release tablets.METHODS:Taking biodegradable Zein as stent material and adhesive material, fluorouracil as model drug, the gastrointestinal controlled release tablets were prepared. The chip technology was orthogonally designed to optimize the choice of coating solution, the in vitro bioadhesion of controlled release tablets and the correlation of in vivo and in vitro were also been studied.RESULTS AND CONCLUSION:The fluorouracil Zein bioadhesive tablets were in line with zero-grade release characteristic in vitro within 10 hours. The prepared gastrointestinal bioadhesive controlled release tablets have good adhesive properties.Moreover, the blood drug concentration in vivo within 2-8 hours was relatively stable , without obvious peak valley, and there was a good correlation of the release and absorption in vivo and in vitro.关键词
玉米醇溶蛋白/生物可降解材料/生物黏附/控释片/体内外相关性分类
医药卫生引用本文复制引用
谢俊俊,吴鸿飞,鲁传华,张群卫,鲁涛..应用生物可降解材料玉米醇溶蛋白制备胃肠道生物黏附控释片[J].中国组织工程研究与临床康复,2011,15(12):2146-2148,3.基金项目
国家自然基金资助项目(81001703). （81001703）
