重庆医学2011，Vol.40Issue(13)：1269-1271,3.DOI:10.3969/j.issn.1671-8348.2011.13.008
雌激素受体基因多态性与子宫内膜异位症、子宫肌腺症的相关性研究
Study of relationship between polymorphism of estrogen receptor-alpha gene with endometriosis and adenomyosis
摘要
Abstract
Objective To determine whether polymorphism of estrogen receptoralpha gene( ERα) is associated with adenomyosis and endometriosis in Shanghai area Chinese Hans population.Methods Determination of polymorphisms in the FRa gene was performed by polymerase chain reaction( PCR) restriction fragment-length polymorphism( RFLP) analysis in 56 affected endometriosis,68 adenomyosis patients and 78 normal controls respectively.Results The genotype frequencies of Pvu Ⅱ pp Pp PP were 38.2％ , 42.6％ ,19.1％ , and XbaⅠ xx Xx XX were 61.7％, 32.4％ , 5.4％ in the patients of adenomyosis.The genotype frequencies of Pvu Ⅱ pp Pp PP were 44.6％,37.5％,17.9％ and Xba Ⅰ xx Xx XX were 64.2％,32.1％ and 3.6％ in the patients of endometriosis.The genotype frequencies of Pvu Ⅱ pp Pp PP were 39.7％ , 48.7％ ,11.5％ and Xba Ⅰ xx Xx XX were 56.4％ ,41.0％and 2.6％ in control, respectively.No significant difference in the frequency of either of Pvull and Xba Ⅰ polymorphisms in the ERα gene was found between endometriosis or adenomyosis patients and the control(P＞0.05).There was no relationship between the polymorphisms in the estrogen receptor alpha with stage of endometriosis also.Conclusion Polymorphism in the gene encoding for ERα probability is not correlated with the occurrence of endometriosis and adenomyosis in Shanghai area Chinese Hans population.关键词
受体,雌激素/子宫内膜异位症/基因多态性/子宫肌腺症引用本文复制引用
陈富强,汪爱萍,范丽安,杨玉琴..雌激素受体基因多态性与子宫内膜异位症、子宫肌腺症的相关性研究[J].重庆医学,2011,40(13):1269-1271,3.基金项目
上海市浦东新区社会发展局科研基金资助项目(PW-2003-A2). （PW-2003-A2）
