重庆医学2011，Vol.40Issue(14)：1367-1369,后插1,4.DOI:10.3969/j.issn.1671-8348.2011.14.007
食管鳞状细胞癌组织中FAK、Paxillin和MMP-9蛋白的表达及临床意义
Expression and clinical significance of FAK,Paxillin and MMP-9 protein in esophageal squamous cell carcinoma tissue
摘要
Abstract
Objective To explore the expressions of FAK,Paxillin and MMP-9 proteins in esophageal squamous cell carcinoma (ESCC) tissues and their significances.Methods Immunohistochemical SP method was used to detect the expressions of FAk,Paxillin and MMP-9 proteins in 59 cases of ESCC tissues,27 cases of adjacent atypical hyperplasia epithelium and 36 cases of normal esophageal epithelium,and the relationships between three proteins above and clinicopathological features were analyzed.Results The protein expression levels of FAK,Paxillin and MMP9 in ESCC tissues were significantly higher than those in the adjacent atypical hyperplasia and normal mucous tissues,and there was significant difference(P＜0.05).The expressions of FAK and Paxillin proteins were both closely correlated with the tumor grade, infiltrative depth and lymph node metastasis in ESCC tiissues(P＜0.05), whereas the expression of MMP-9 protein was tightly correlated with the tumor grade and lymphatic metastasis in esophageal squamous cell carcinorna(P＜0.05).Further,correlation analysis revealed that expressions of FAK and Paxillin proteins were both positively related to the expression of MMP-9 protein(P＜0.05)(r=0.299 and 0.464 ,P=0.022 and 0.000 , respectively).Conclusion Overexpressions of FAk, Paxillin and MMP-9 proteins may play pivotal roles in the invasiveness and metastasis of ESCC,which can be achieved via the regulation of MMP9 expression.关键词
食管/肿瘤,鳞状细胞/黏着斑激酶/桩蛋白/基质金属蛋白酶9/肿瘤转移/浸润引用本文复制引用
庞霞,李晟磊,赵志华,赵阿红,张红新,高冬玲..食管鳞状细胞癌组织中FAK、Paxillin和MMP-9蛋白的表达及临床意义[J].重庆医学,2011,40(14):1367-1369,后插1,4.基金项目
河南省基础与前沿技术研究项目(082300453202). （082300453202）
