重庆医学2011，Vol.40Issue(14)：1386-1387,1390,后插2,4.DOI:10.3969/j.issn.1671-8348.2011.14.013
幽门螺杆菌感染、端粒酶活性与胃癌、癌前病变关系的研究
Relationship between infection of Helicobacter pylori and telomerase activity in gastric cancer and precancerous lesions
伍冬梅 1李春鸣 2张赟3
作者信息
- 1. 遵义医学院组胚教研室,贵州遵义,563003
- 2. 遵义医学院病理教研室,贵州遵义,563003
- 3. 贵州省人民医院病理科,贵阳,550002
- 折叠
摘要
Abstract
Objective To study the effect and correlation of infection of Helicobacter pylori and telomerase activity in gastric cancer , precancerous lesions.Methods Hp infection was detected by Warthin -Starry method , hTERT protein expressiun was examined by immunohistochemtcal technique SP,hTERT mRNA expression was examined by situ hybrtdization.Results Hp infection,the positive expression rate of hTERT protein and hTERT mRNA in intestnal metaplasia,epithelial dysplasia of stomach and gastric carcinomas were significantly higher than normal gastritis mucosa.The positive expression rate of hTERT protein in 93 cases of gastric mucosa lesion of positive Hp infection was 88.17％ , which was significantly higher than 47.46％ in 59 cases of negative Hp infection(P＜0.01).The positive expression rate of hTERT mRNA with positive hTERT protein was significantly higher than that with negative hTERT protein(P＜0.01).Conclusion Hp infection, hTERT protein and hTERT mRNA are associated with gastric carcinomas, Hp infection can result in increased expression of hTERT protein and then activate telomerase, which may be one of molecular mechanism by which Hp infection leads to gastric carcinoma.关键词
胃肿瘤/癌前状态/螺杆菌,幽门/端粒,末端转移酶引用本文复制引用
伍冬梅,李春鸣,张赟..幽门螺杆菌感染、端粒酶活性与胃癌、癌前病变关系的研究[J].重庆医学,2011,40(14):1386-1387,1390,后插2,4.
