中国组织工程研究与临床康复2011，Vol.15Issue(12)：2195-2198,4.DOI:10.3969/j.issn.1673-8225.2011.12.026
比较纳米羟基磷灰石/聚酰胺66人工椎体与自体髂骨在颈椎前路减压融合中的应用
Comparison between nano-hydroxyapatite and polyamide 66 composite artificial vertebral body and iliac bone autograft in anterior cervical decompression and fusion
摘要
Abstract
BACKGROUND: Plenty of materials, such as autogenous iliac bone, allogeneic bone, and titanium mesh, are used for anterior cervical reconstruction, with each advantages and disadvantages. Nano-hydroxyapatite and polyamide 66 (n-HA/PA66) artificial vertebral body has good biocompatibility and biological safety and is an ideal substitute for vertebral body bone graft.OBJECTIVE: To study clinical effect and difference between the n-HA/PA66 composite artificial vertebral body and the iliac bone autograft in anterior cervical decompression and fusion for treatment of cervical spondylotic myelopathy.METHODS: From January 2009 to March 2010, 40 cases of cervical spondylotic myelopathy were treated with anterior cervical su btotal corpectomy and fixed by titanium locking plates. 22 im planted with n-HA/PA66 composite artificial vertebral body and 18 with iliac bone autograft. The JOA grading system was done in follow up to evaluate neural symptoms, and Cobb's angle was measured to evaluate the change of cervical curvature, interverberal height, fusion number at postoperative 6 months was measured.RESULTS AND CONCLUSION : All patients were followed up for 6-14 months. The JOA grading was greatly improved in both groups. But there were significant differences on interverberal posterior height and restoring lordosis of fusion segment at different time intervals (P ＜ 0.01). According to fusion criteria, difference between the two methods was not significant at 6 months and 3 months after treatment (P ＞ 0.05). n-HA/PA66 composite artificial vertebral body was the same fusion rate as iliac bone autograft, and could effectively maintain the biological alignment and cervical intervertebral height. The long-term effects depend on further follow-up.关键词
纳米羟基磷灰石/聚酰胺/颈椎病/自体髂骨/前路植骨融合/Cobb角分类
医药卫生引用本文复制引用
陈豪,王利民,谭洪宇,刘屹林,王卫东,杨朝垒..比较纳米羟基磷灰石/聚酰胺66人工椎体与自体髂骨在颈椎前路减压融合中的应用[J].中国组织工程研究与临床康复,2011,15(12):2195-2198,4.基金项目
国家科技支撑计划课题--活性纳米复合生物材料制品手术示范与临床应用(2007BAE13B00). （2007BAE13B00）
