中国全科医学2011，Vol.14Issue(11)：1222-1224,3.
胰岛素泵对初诊2型糖尿病患者内皮依赖性舒张功能及3-硝基酪氨酸的影响
Effects of Insulin Pump on Endothelia-dependant Flow-mediated Vasodilatation and Serum 3-nitrotyrosine in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
牛鑫鑫 1姚璐 2吕肖锋 2高宇 3杨鹏飞 2王素玲 2武晋晓 2焦秀敏 2张星光 2赵晶2
作者信息
- 1. 第三军医大学
- 2. 100700,北京市,北京军区总医院内分泌科
- 3. 100700,北京市,北京军区总医院超声科
- 折叠
摘要
Abstract
Objective To investigate the effects of short - term insulin pump therapy on flow - mediated dilatation ( FMD ) and serum 3 - NT concentration in patients with newly diagnosed type 2 diabetes mellitus. Methods 40 patients with newly diagnosed type 2 diabetes mellitus were selected as DM group and 30 age - and sex - maatched healthy people were selected as NC group. In the two groups, blood sugar,hlood fat and glycosylated hemoglobin were tested, FMD was tested by high resolution ultrasound detection, and serum 3 - NT concentration was tested by enzyme linked immunosorbent assay ( ELISA ) detection. Besides, fasting insulin was measured and HOMA - IR was calculated in DM group. After intensive therapy by insulin pump for 2 weeks, FMD and serum 3 - NT concentration were reexamined in DM group. Results ( 1 ) Compared with the NC group, the T2DM group had significantly lower HDL - C and FMD. and higher glycosylated hemoglobin, blood glucose and hlood fat as well as serum 3 - NT concentration ( P＜0. 05 ). ( 2 ) After two - week insulin pump therapy, FMD in DM group increased from ( 4. 54 ± 1. 42 )％ to ( 7. 20 ±2. 59 )％ ( P ＜0. 01 ). serum 3 - NT concentration decreased from ( 118 ± 13 ) nmol/L to ( 112 ± 11 ) nmol/L ( P ＜ 0. 01 ).The difference was statistically significant ( P ＜ 0. 01 ). ( 3 ) Correlation analysis showed that 3 - NT level had positive correlation with glycosylated hemoglobin and fasting plasma glucose but negative correlation with FMD ( P ＜ 0. 01 ). Conclusion Intensive treatment by insulin pump can increase FMD and decrease 3 - NT concentration in patients with newly diagnosed type 2 diabetes mellitus.关键词
糖尿病/2型/3-硝基酪氨酸/血管内皮依赖性舒张功能/胰岛素泵强化治疗分类
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牛鑫鑫,姚璐,吕肖锋,高宇,杨鹏飞,王素玲,武晋晓,焦秀敏,张星光,赵晶..胰岛素泵对初诊2型糖尿病患者内皮依赖性舒张功能及3-硝基酪氨酸的影响[J].中国全科医学,2011,14(11):1222-1224,3.
