中国兽医科学2011，Vol.41Issue(2)：205-209,5.
感染旋毛虫小鼠的心肌CPT1mRNA表达量及血脂变化
Observation on changes of CPT1 mRNA expression and blood lipid in myocardium of mice infected with Trichinella spiralis
摘要
Abstract
To explore the influence of Trichinella spiralis infection on host's lipoprotein metabolism and myocardial damage,carnitine palmitoyl-transferase 1 (CPT1) mRNA expression was determined using semi-quantitative RT-PCR and blood lipid components were detected during T. spiralis infection in mice. In result,the expression level of CPT1 increased from 0.37 before infection to 0.93 on day 19 post-infection,and then decreased to 0.46 on day 52 post-infection,indicating that bioactivity of CPT1 increased after infection and the metabolism of fatty acids enhanced. Test of plasma lipid showed that the average concentration of TG was higher and HDL was lower compared with that of the control group,0.43 mmol/L and 2.14 mmol/L respectively. These result showed that the mice myocardium suffered from lipids metabolic disorder post-infection with T. spiralis.关键词
旋毛虫/肉毒碱脂酰转移酶1/mRNA表达/血脂分类
农业科技引用本文复制引用
李晓云,韩彩霞,路义鑫,赵风强,宋铭忻..感染旋毛虫小鼠的心肌CPT1mRNA表达量及血脂变化[J].中国兽医科学,2011,41(2):205-209,5.基金项目
国家"十一五"科技支撑计划重大项目(2010BAD04B01) （2010BAD04B01）
家畜疫病病原生物学国家重点实验室开放课题(SKLVEB2009KFKT005) （SKLVEB2009KFKT005）
黑龙江省普通高等学校青年学术骨干支持计划项目(1153G007) （1153G007）
