中德临床肿瘤学杂志（英文版）2011，Vol.10Issue(2)：81-84,4.DOI:10.1007/s10330-011-0729-3
骨转换标志物在非小细胞肺癌骨转移临床应用价值的研究
Clinical application value of bone turnover markers in non-small-cell lung cancer patients with bone metastases
摘要
Abstract
Objective: The purpose of this study was to assess the clinical application value of bone turnover markers in non-small-cell lung cancer (NSCLC) patients with bone metastases. Including diagnosing bone metastases, detecting bone metastatic spread. Methods: Alkaline phosphatase (AKP), β-C-terminal telopeptide of type Ⅰ collagen (β-CTx), osteocalcin (OST) and bone alkaline phosphatase (BALP) were measured in 76 patients with bone metastases from NSCLC and 44 normal people. Results: The level of AKP, β-CTx and BALP in patients with bone metastasis was significantly higher than in the normal people. Significant correlation was observed among bone turnover markers. The levels of BALP and OST were significantly correlated with the extent of bone metastasis. The patients with high-level CTx and low-level BALP had higher risk of pathologic fracture. Conclusion: In NSCLC patients with bone metastases, bone turnover markers can help to make diagnosis and evaluate the severity. It will have a wide range of use in clinical practice.关键词
non-small-cell lung cancer/ bone metastasis/ bone turnover markersKey words
non-small-cell lung cancer/ bone metastasis/ bone turnover markers引用本文复制引用
Zhiyu Wang,Chen Yang,Yumei Yang,Zan Shen,Hui Zhao,Yang Yao..骨转换标志物在非小细胞肺癌骨转移临床应用价值的研究[J].中德临床肿瘤学杂志（英文版）,2011,10(2):81-84,4.基金项目
Supported by grants from the Foundation of Shanghai Shenkang Hospital Development Centre (No.SHDC12007304) and Shanghai Public Health Bureau (No.2009086). （No.SHDC12007304）
