中国药业2011，Vol.20Issue(4)：17-19,3.
治疗药物监测与药物基因组学
Therapeutic Drug Monitoring and Pharmacogenomics
鲍红荣 1赵志刚2
作者信息
- 1. 浙江省临安市人民医院临床药学室,浙江临安,311300
- 2. 首都医科大学附属北京天坛医院药剂科,北京,100050
- 折叠
摘要
Abstract
Objective To apply pharmacogenomics in clinical rational drug use to provide the basis for clinical individualized medication.Methods Through retrieving literatures, the problems found in clinical practice of therapeutic drug monitoring (TDM) were summarized, and the development and characteristics of pharmacogenomics were elaborated. Results The gene polymorphism is the most important factor that the medication effects vary from person to person. Through pharmacogenomics studies, realizing the individualized treatment is further extension and enrichment of TDM. Application of pharmacogenomics to clinical rational drug use remedies the shortage of previous individualized medication only according to drug concentration and also finds the answer to the phenomenon of pharmacedynamics can not being explained before, which opens up a new way for clinical personalized medication. Conclusion Future clinical pharmacotherapy model should be oriented with genetic pharmacology and pharmacogenomics, combined with blood drug concentration monitoring, and guide the rational use of particular drugs to patients.关键词
治疗药物监测/药物基因组学/基因多态性/药物代谢酶/个体化给药分类
医药卫生引用本文复制引用
鲍红荣,赵志刚..治疗药物监测与药物基因组学[J].中国药业,2011,20(4):17-19,3.
