实用医学杂志2011，Vol.27Issue(7)：1173-1175,3.DOI:10.3969/j.issn.1006-5725.2011.07.018
PIK3CA在胃癌组织中的表达及其与转移的关系
PIK3CA expression in gastric cancer tissues and the correlation between PIK3CA and metastasis
摘要
Abstract
Objective To explore PIK3CA expressions in gastric cancer tissues and the correlation between PIK3CA expression and metastasis. Methods PIK3CA mRNA and protein levels of normal gastric mucosa, primary gastric cancer tissues, gastric cancer specimens in lymph node metastasis and distant metastasis were detected respectively by Real-time quantitative PCR and immunohistochemistry. In addition , the difference of PIK3CA expression in each group and their relationship with clinical pathological characteristics were analyzed.Results PIK3CA mRNA in lymph node metastasis group was the highest, which was approximately 5 and 2 fold, as that in normal gastric mucosa and primary gastric cancer tissues, respectively (P ＜ 0.05). While was not statistically different with that in distant metastasis group (P ＜ 0.05). The positive rate of PIK3CA protein expression was significantly higher in lymph node metastasis and distant metastasis gastric cancer specimens than that in primary gastric cancer tissues (67％ vs 35％ , P = 0.015 ; 61％ vs 35％ , P = 0.044). Additionally , high expression of PIK3CA protein in gastric cancer tissues was associated with lymph node metastasis (P ＜ 0.05) ,but wasn't associated with other factors such as patient's sex, age, and clinical stage. Conclusion High expression of PIK3CA might play a vital role in tumorigenesis and progression of gastric cancer. Its expression level might be an important indicator to evaluate gastric cancer metastasis.关键词
胃肿瘤/PIK3CA/转移引用本文复制引用
周新科,刘季芳,张蒙夏,雷小勇,唐圣松..PIK3CA在胃癌组织中的表达及其与转移的关系[J].实用医学杂志,2011,27(7):1173-1175,3.基金项目
湖南省自然科学基金项目(编号:09JJ3060) （编号:09JJ3060）
湖南省高校科技平台基金(编号:09A072) （编号:09A072）
广东省医学科研基金项目(编号:A2007284) （编号:A2007284）
