南京医科大学学报（自然科学版）2011，Vol.31Issue(2)：190-192,259,4.
甲基强的松龙对脊髓损伤后下丘脑室旁核FOS和NOS表达的影响
Effects of methylprednisolone on FOS and NOS expressions in the hypothalamic paraventricular nucleus following the spinal cord injury
摘要
Abstract
Objective: To observe the effects of methylprednisolone (MP) on expressions of FOS and NOS in the paraventricular nucleus (PVN) of the hypothalamusfollowing the acute spinal cord injury(SCI). Methods:The total of 36 adult SD rats were randomly divided into 3 groups: control group, SCI group and MP treatment group. The rats in SCI and MP treatment groups were received the spinal transection at the fourth thoracic segment(T4). MP treated rats were given intravenous injection MP(30 mg/kg) for once, or once daily for one week or four weeks, respectively. FOS and/or NOS positive neurons were mapped in the PVN using NADPH-d histochemistry combined with Fos immunohistochemistry. Results:Compared with control group, the numbers of FOS positive neurons and NOS positive neurons were increased in the PVN, which were decreased following MP treatment for one week or four weeks. Conclusion:MP may have the protective effects on neurons in the PVN following the SCI.关键词
甲基强的松龙/脊髓损伤/室旁核/FOS/NOSKey words
methylprednisolone(MP)/ spinal cord injury/ paraventricular nucleus(PVN)/ FOS/ NOS分类
医药卫生引用本文复制引用
李雪甫,王永实,傅玉峰,陈培,肖明,丁炯..甲基强的松龙对脊髓损伤后下丘脑室旁核FOS和NOS表达的影响[J].南京医科大学学报（自然科学版）,2011,31(2):190-192,259,4.基金项目
淮安市科技发展基金项目(HAS07050) （HAS07050）
