现代妇产科进展2011，Vol.20Issue(2)：88-91,4.
卵巢癌组织中STAT3和免疫效应细胞的表达及其相关性分析
Expression and relativity of STAT3 and immunity effect cell in epithelial ovarian carcinoma
管东东 1张磊磊 1王云芳 1王志红 1魏双燕 1汪辉2
作者信息
- 1. 滨州医学院附属医院妇产科,滨州,256603
- 2. 华中科技大学同济医学院附属同济医院妇产科
- 折叠
摘要
Abstract
Objective : To study the expression of STAT3 , DC, CD4+ , CD8+ in ovarian epithelidl carcinoma and explore the relationship between them and the clinical significance,to discuss a mechanism of the tumor escaping immunity surveillance in the ovary occurrence process. Methods: Tissue samples from 42 women with primary ovarian epithelial carcinoma ( OVCA) ,25 with benign ovarian tumor ( OVBT) and 13 with normal ovarian tissue ( NOV) were collected. SABC immunohistochemical staining was used to determine the expression of STAT3 and DC , CD4+ , CD8+ , also carry on half fixed amount and relativity analysis. Results:( 1 ) Semi-quantitative scoring showed that STAT3 expression in OVCA was significantly higher than that in OVBT and NOV ( P＜0. 005 ) . In OVCA, tumor tissue expressed STAT3 at signifieantly higher levels in Ⅲ～Ⅳ than Ⅰ～Ⅱ by the FICO staging( P＜0. 05) . (2) DC.CD4+ was lower expressed significantly in OVCA than that in OVBT and NOV ( P＜0. 005 ) . Tumor tissue expressed DC,CD4+ at significantly lower levels in Ⅲ ～Ⅳ than Ⅰ～Ⅱ by the FIGO staging(P＜0. 05 ) . ( 3) CD8+ was also lower expressed significantly in OVCA than that in OV BT and NOV (P＜0.005). The Ⅲ～Ⅳ and Ⅰ～Ⅱ comparison by the FIGO staging,the low expression rate increased , but had no significant differences ( P＞0. 05 ) . ( 4 ) The level of STAT3 expression was negatively related with level of DC , CD4+ and CD8+( P＜0. 05 ) . Conclusion : The expressions of STAT3 and DC , CD4+ ,CD8+ may play an imponant role in the development of ovarian tumors.The ovarian epithelial carcinomas with STAT3 higher expression and those with DC, CD4+,CD8+ lower expression might have worse prognosis. STAT3 inhibited the function of DC , CD4+,CD8+T cell, which might be one of the mechanisms of tumor evasion of immune surveillance.关键词
卵巢肿瘤/免疫组织化学/肿瘤浸润淋巴细胞/免疫逃逸信号转导及转录活化因子3/树突状细胞分类
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管东东,张磊磊,王云芳,王志红,魏双燕,汪辉..卵巢癌组织中STAT3和免疫效应细胞的表达及其相关性分析[J].现代妇产科进展,2011,20(2):88-91,4.
