山东医药2011，Vol.51Issue(8)：30-32,封3,4.
荞麦黄酮复方制剂对2型糖尿病大鼠胰岛素抵抗的影响
Effect of flavones of buckwheat compound in type 2 diabetic rats with insulin resistance
摘要
Abstract
Objective To study the effect of flavones of buckwheat compound ( FBC) on serum glucose, serum lipid and insulin resistance in type 2 diahetic rats and try to find its mechanism.Methods The models of diabetic type 2 rats with insulin resistance were made by injecting streptozotocin ( STZ) and eating a high-fat diet.Rats were randomly divided into normal group, model group, FBC low and high (0.6 and 1.2 g/kg) groups and xiaoke group.Fasting blood glucose ( FBG) , OGTT, fasting insulin ( FINS) , insulin sensitivity dex (ISI) , free fatty acids ( FFA) , triglyceride ( TG) , total cholesterol ( TC ) were measured after 8 weeks.The pancreas , liver tissues were stained by HE so as to observe its morphologic changes.Results FBG, TG, TC , FFA significantly reduced in the FBC groups as compared with those in the model group , while ISI significantly increased and improved OGTT ( P ＜ 0.05 or P ＜ 0.01).Corupared with the model group, the pathologic changes of the pancreas and liver tissues were significantly improved in different dose FBC groups.Conclusion FBC can significantly reduce FBG, improve insulin resistance by the mechanism of regulating serum lipid.关键词
荞麦黄酮复方制剂/2型糖尿病/胰岛素抵抗分类
医药卫生引用本文复制引用
梁永平,韩淑英,王志路,赵剑璞,魏倩璞,李淑敏..荞麦黄酮复方制剂对2型糖尿病大鼠胰岛素抵抗的影响[J].山东医药,2011,51(8):30-32,封3,4.基金项目
河北省教育厅科技攻关项目(2006320) （2006320）
唐山市"十一五"重点工程项目(072631B-1) （072631B-1）
河北省自然科学基金资助项目(C2010001795). （C2010001795）
