山东医药2011，Vol.51Issue(8)：33-34,105,3.
二味中药复方治疗腹泻型肠易激综合征的实验研究
Effect of LWZY on motility and cholecystostomy in rats with diarrhea predominant irritable bowel syndrome
摘要
Abstract
Objective To observe the effect of LWZY decoction on model rats which had diarrhea predominant irritable bowel syndrome (IBS) with liver depression and spleen deficiency. Methods The rat model used in integer study was "wrap-restraint stress" after perfused sennae solution. The treatment lasted 7 days. The decoction had small, middle and large dose level. The levels of motility (MOT) and cholecystostomy (CCK) in plasma and descending colon tissue were observed. Results Middle and high dose of LWZY could significantly change the rat loose stools class. IBS model rats had a higher content of CCK in colon tissue, and the decoction of LWZY could modulate it to be normal. But MOT had no significant changes neither in plasma nor in tissue. Conclusion LWZY can treat IBS effectively, which maybe correlate with modulating the content of CCK in colon tissue.关键词
肠易激综合征/二味中药/胃动素/胆囊收缩素分类
医药卫生引用本文复制引用
张道英,李洪亮,范小娜,曾靖..二味中药复方治疗腹泻型肠易激综合征的实验研究[J].山东医药,2011,51(8):33-34,105,3.基金项目
江西省教育厅科研课题(赣教技字[2005]248). （赣教技字[2005]248）
