中国肺癌杂志2011，Vol.14Issue(2)：146-150,5.DOI:10.3779/j.issn.1009-3419.2011.02.08
非小细胞肺癌组织中ZO-1的表达及其临床意义
Expression and Clinical Significance of ZO-1 in Patients with Non-small Cell Lung Cancer
摘要
Abstract
Background and objective It has been proven that the expression of ZO-1 (zonula occluden-1) was correlated with the growth and metastasis of cancer.The aim of this study is to investigate the relationship between ZO-1 gene expression and clinicopathologic parameters and the survival rates in the patients with non-small cell lung cancer (NSCLC).Methods The expression levels of ZO-1 gene in 101 patients with NSCLC and lung tissues of 61 patients with benign lung disease were detected by real-time PCR, Western blot and immunohistochemical techniques.Results There was a significant statistic difference of ZO-1 mRNA expression levels between carcinoma group and control group (P＜0.01).In carcinoma group,adjacent group and control group, ZO-1 protein expression levels were with significantly statistic difference between each other (P＜0.01 or P＜0.05).Ihere was a significantly statistic difference between ZO-1 mRNA expression levels in survival during 2 years follow-up group and death during 2 years follow-up group (t=-5.61, P＜0.01).Conclusion ZO-1 is a valuable predictive marker for NSCLC patients.关键词
ZO-1蛋白/肺肿瘤/免疫组织化学分类
医药卫生引用本文复制引用
王晔恺,周吉航,曾芳,黄燕燕,周世权,刘晓光..非小细胞肺癌组织中ZO-1的表达及其临床意义[J].中国肺癌杂志,2011,14(2):146-150,5.基金项目
本研究受舟山市卫生局医药科研计划项目(No.2008B005)资助 （No.2008B005）
