同位素2011，Vol.24Issue(1)：29-33,5.
99Tcm-BnAO-乙二醇独甲醚的合成及其生物分布
Synthesis, Radiolabeling and Biodistribution of 99Tcm-BnAO Ethylene Glycol Monoethyl Ether Derivate
摘要
Abstract
Hypoxic cells within a tumor is associated with the radiotherapy and chemotherapy resistance. The development of noninvasive methods for detecting hypoxia is need.99 Tcm-BnAO is a non-nitroimidazole imaging agent for hypoxia,and has been evaluated both in vitro and in vivo as a noninvasive marker. In order to improve its ability for imaging, the ligand BnAOwas modified with ethylene glycol monoethyl ether (EGME) on both sides.BnAO and BnAO-EGME were labeled with 99Tcm. 99Tcm-BnAO and 99Tcm-BnAO-EGME were found to be electrically neutral at physiological condition by paper electrophoresis.99Tcm-BnAO-EGME showed higher hydrophilicity in octanol/water partition coefficient experiment and better stability in vitro. The biodistribution in mice bearing S180 tumor demonstrated that 99Tcm-BnAO and 99Tcm-BnAO-EGME could accumulate in tumor with time going. However, it was found that 99Tcm-BnAO-EGME showed a little disadvantage in the ratio tumor to blood and the ratio of tumor to muscle compared with 99Tcm-BnAO.关键词
99Tcm-BnAO/乙二醇独甲醚/生物分布Key words
99Tcrm-BnAO/ ethylene glycol monoethyl ether/ biodistribution分类
能源科技引用本文复制引用
黄华璠 ,周浩,黄士堂,褚泰伟..99Tcm-BnAO-乙二醇独甲醚的合成及其生物分布[J].同位素,2011,24(1):29-33,5.基金项目
国家自然科学基金资助项目(20771011,21071010) （20771011,21071010）
